Latest publications at pubmed or google scholar. Selected preprints and publications:
- Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved tran- scriptomics, metabolomics, and proteomics. By deciphering regionally shared transcriptional programs across patients, we inferJuly 29, 2022 - T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-10-releasing HMOX1+ myeloidJuly 29, 2022 - Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma
Glioblastoma cells assemble to a syncytial communicating network based on tumor microtubes (TMs) as ultra-long membrane protrusions. The relationship between network architecture and transcriptional profile remains poorly investigated. Drugs that interfere within this syncytial connectivity such as meclofenamate (MFA) may be highly attractive for glioblastoma therapy. In a human neocortical slice model using glioblastoma cellApril 28, 2021 - Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. However, the source for dynamic reorganization of cellular states within their spatial context remains elusive. Here, we in-depth characterized glioblastomas by spatially resolved transcriptomics,March 21, 2021 - Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
Reactive astrocytes evolve after brain injury, inflammatory and degenerative diseases, whereby they undergo transcriptomic re-programming. In malignant brain tumors, their function and crosstalk to other components of the environment is poorly understood. Here we report a distinct transcriptional phenotype of reactive astrocytes from glioblastoma linked to JAK/STAT pathway activation. Subsequently, we investigate the origin ofJune 11, 2019